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Must be examined carefully, but it is especially important for topics such as genetic testing for which there is possibility of considerable profit involved. Table 7 provides some useful Web sites that can provide additional information regarding genetic polymorphisms involved in drug metabolism. CONCLUSIONS Undoubtedly, this is an exciting time for individualized pharmacotherapy and personalized medicine as pharmacogenomic tools, including AmpliChip, are introduced into clinical practice. Pharmacogenomics will come into mainstream clinical practice very rapidly as many regulatory authorities have instituted regulatory guidelines of pharmacogenomic genotyping during the drug development process. However, the impact of pharmacogenomics on clinical therapeutics will ultimately depend on its clinical applicability and demonstrated use. There are clearly some specific questions pharmacogenomics will assist in understanding. With greater clinical experience, the surfeit of applications of pharmacogenomics will unravel. ACKNOWLEDGEMENTS The authors have no conflict of interest with any of the products or companies discussed in this article. The authors would like to thank Ms. Terri Rothwell for her assistance with manuscript preparation. REFERENCES.
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Converting atrial fibrillation, which is a much more serious problem. These are problems still to be solved. From the engineering standpoint the problems or tasks are 1 ; achieving very reliable recognition of the onset of the arrhythmia so that the drug is released only when at the right time; 2 ; optimal operation of the pump from a pharmacokinetic sense, and 3 ; making the implant small enough to be acceptable to patients. I think they are well in hand. The problems that need to be addressed now are the clinical problems. Studies need to be done in which rapid drug delivery is done in the lab under controlled circumstances with patients who have atrial fibrillation. The safety and efficacy of this kind of thing must be well demonstrated long before we can start implanting patients. Nebeker: Arzbaecher: Are you working on some of these problems at your lab at IIT? Indirectly. The idea of an implanted drug pump for the treatment of atrial fibrillation is a concept that has developed in my laboratory at IIT, so the intellectual property belongs to IIT. IIT has been trying to license the patent to an appropriate company in order to move on to the next stages of development. Three years ago ITT licensed to a startup company in Minneapolis, but after a couple of years of very good work in developing the hardware and refining and getting additional patent protection the company went bankrupt. IIT has revoked the license and is now looking for another company with which it can continue this work. When we find the licensing company that will carry this technology to the next stage work will probably continue to be done at ITT. Certainly that was the case with this startup in Minneapolis. I was actively involved in my laboratory 23.

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